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| 580.470 Biomedical Instrumentation II: Molecules & Cells |
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Course Overview |
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| This core design course is tailored to explore the fundamentals of molecular and cellular measurements, related technologies and their applications in scientific research. The course will include a guided lab and challenging hands-on group projects. Emphasis will be on prevalent microtechnologies applied to developing instrumentation capable of handling cells and biological molecules, their manipulation, detection and measurements. The course will also involve a term paper consisting of a literature review on such technology. Students will research specialized instrumentation and present this in class. |
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Course Administration |
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| Instructor |
Dr. Nitish Thakor
Dr. Leslie Tung |
nitish@jhu.edu
ltung@jhu.edu
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Teaching
Assistants |
Rezina Siddique |
rsiddiq2@jhmi.edu |
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| Project Mentors |
Suneil Hosmane, Abhishek Rege, Kartikeya Murari |
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| Timings |
Lecture Timings:
Lab Timings:
TA Office Hours: |
4:00pm - 5:15pm on Thursdays
1:00pm - 3:00pm on Fridays
TBD |
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| Location |
Lectures:
Labs: |
Barton Hall 114
Clark Hall 119 (unless otherwise stated) |
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| Grading |
Labs & Assignments
Student Presentations & Term Paper
Final Project |
50%
20%
30% |
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Lecture Notes |
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| Lecture 1 |
Molecules and Cells (Thakor) |
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| Lecture 2 |
Microfabrication (Hosmane) |
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| Lecture 3 |
Microfluidics (Rege) |
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| Lecture 4 |
Fluidics in vitro Studies (Thakor) |
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| Lecture 5 |
Biosensors (Thakor) |
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| Lecture 6 |
Bioelectricity (Tung) |
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| Lecture 7 |
Molecular Sensing (Thakor) |
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| Lecture 8 |
Cellular Sensing (Tung) |
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| Lecture 9 |
Advanced Microfabrication (Gracias) |
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| Lecture 10 |
MicroBio Systems (Thakor) |
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| Lecture 11 |
NanoBio Systems (Mao) |
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Labs |
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| Lab 1 |
Mask Design for Photolithography (Microfab Lab) |
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| Lab 2 |
Template Making with Lithography (Microfab Lab) |
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| Lab 3 |
Microfluidic Devices with PDMS (Microfab Lab) |
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| Lab 4 |
Simulation of Microfluidic Applications (HAC Lab) |
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| Lab 5 |
Testing Microfluidic Devices (Microfab Lab) |
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| Lab 6 |
Cell/Particle Counters (Instrumentation Lab) |
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| Note that while entering the lab every week, the student is required to hand over to the TAs: |
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Answers to the pre-lab questions for that particular lab |
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Answers to the post-lab questions for the previous lab |
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Assignments |
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| Assignment 1 |
Mask Design |
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| Assignment 2 |
Microfluidics for Biomedical Applications |
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Projects |
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| Project 1 |
Christmas Tree Gradient Generator for Cell Differentiation Study |
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| Project 2 |
Electrochemical Sensors for Biomolecules |
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| Project 3 |
On-Stage Incubator for Long Term Cell Studies |
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| Project 4 |
Self Assembled Monolayers (SAMs) for Time-Controlled Desorption |
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| Project 5 |
Cell Tracking for Motile Cells or Cellular Processes |
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Textbook/Reading |
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| Microfabrication |
Marc Madou, Fundamentals of Microfabrication, CRC Press. |
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| Microfluidics |
Ch 1‒5 of Streeter and Wylie, Fluid Mechanics, McGraw-Hill, 1998 |
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| Imaging |
Online content by Nikon: http://www.microscopyu.com/sitemap.html |
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Copyright © 2008 JHU Neuroengineering & Biomedical Instrumentation Lab
All rights reserved. |
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