Overexpression of K16 in transgenic mouse skin
This micrograph depicts mouse epidermis dual-immunostained, via indirect immunofluorescence, for endogenous keratin 10, see here via the red chromophore, and transgenic K16 protein, seen via the green chromophore (note that yellow implies coincidence of read and green signals). Higher levels of K16 are associated with an intriguing follicular keratosis in transgenic mouse skin. This work was conducted by Kenzo Takahashi, a former postdoctoral fellow in the laboratory. See Takahashi et al., J. Cell Biol. 1994.
