Hair Follicles immunostained for Keratin 17

Immunostaining of a paraffin-embedded tissue section from 3 day-old mouse backskin using a rabbit polyclonal antibody to keratin 17 (K17). Bound primary antibodies are detected using a peroxidase-based detection method producing a brownish-colored deposit. Positive immunoreactivity is seen in the outer root sheath and a distinct polarization within the matrix portion to the side opposite to the direction of hair follicle outgrowth. Picture courtesy of Dr. Kevin McGowan, fo former postdoc in the laboratory. Detailed information can be found in McGowan and Coulombe, J. Invest. Dermatol., 2000.