The symbol "Palm of a Hand" is most popular and widely known as the Jain religion symbol.  The palm of the hand signifies this assurance, 'do not be afraid', indicating that human beings who are suffering due to karmic bondage do not need to be disheartened but have faith and change the course of their actions by treading the path of righteousness.  The Wheel of Dharma (Chakra) with 24 spokes represents the religion preached by the 24 Tirthankars (Jain Gods) consisting of Ahimsa (non-violence) in thought, words and action.  It is the distilled essence of the religion.